Serum Adropin Levels in Relation to Nutritional Status in Hemodialysis Patients

Hemodialysis (HD) is an alternate of renal functioning in patients with end stage renal disease (ESRD). Malnutrition is a common problem in patients with end stage renal disease (ESRD) undergoing hemodialysis (HD) that is associated with increased morbidity and mortality. Adropin is a novel pleotropic peptide involved in energy hemostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. To determine the relationship between serum adropin levels and nutritional status and other relevant clinical and laboratory parameter in hemodialysis patients.
The current work a Case control study. A total number of 60 Egyptian patients (20 mild malnourished, 20 moderate malnourished, 20 severe malnourished) with chronic kidney disease patients on regular hemodialysis, they were selected from patients attending the dialysis unit at Al-Zaharaa University Hospital during the period from August 2021 to January 2022 and 20 apparently healthy volunteers. Adropin level was significantly lower in hemodialysis patients (especially in severe HD being 180.42±93.068) compared to control group (403.35±108.021) with p-value <0.001. statistically significant negative correlation between dialysis malnutrition score (DMS) and Adropin level with p-value=0.001. Adropin may a reliable marker that can help in prediction of malnutrition among hemodialysis patients.