High Sensitive C Reactive Protein to Diagnose Inflammatory Mediators in Preeclampsia

Preeclampsia is considered as a serious pregnancy complication. It's one of the most common causes of maternal morbidity and mortality. There is extensive evidence that activation of inflammation is considered as a major contributor in the preeclampsia pathogenesis. To assess serum highly sensitive C-reactive protein level in preeclampsia as an indicator of inflammation and to correlate Hs-CRP with blood pressure. The case-control study was carried out on 85 women attending the outpatient clinic of Al-Zahraa University hospital in the interval from March 2021 till November 2021 according to inclusive and exclusive criteria and tests were done at Allergy & Immunology Center Al-Azhar University. They were divided into two groups: a. Preeclamptic patient group (50 cases) b. Controls: involving 35 healthy normotensive gravid females. Two ml venous blood samples were collected from all females participating in the study for assessment of Hs-CRP level by ultra-sensitive immunoturbidometric technique (ELISA assay). In preeclampsia, serum Hs-CRP levels were significantly higher than normotensive pregnant females (p<0.001). Hs-CRP can assess low grade chronic inflammation. the degree of inflammation increase as Hs CRP rises. In preeclampsia, the systemic inflammatory response is overactive, resulting in production of reactive oxygen species and endothelial impairment. This is the main cause of the clinical symptoms of hypertension and proteinuria in preeclampsia. Early detection can minimize systemic inflammation and maternal death due to preeclampsia. Hence, Hs-CRP may be used as an important indicator of inflammation and severity of preeclampsia.