Micro-Needling Plus Human Placental Extract and Mesenchymal Stem Cell Mesotherapy Versus Micro-Needling in the Treatment of Atrophic Post Acne Scars

Atrophic acne scarring is a prevalent cosmetic issue that may affect 95% of acne patients. It is to assess the effectiveness of human placental extract (HPE) and mesenchymal stem cells (MSC) mesotherapy combined with microneedling versus microneedling alone for the treatment of atrophic acne scars. Thirty patients with post-acne scars participated in the trial. On both sides of the face, microneedling was done. The left half of the face received microneedling and human placental extract (HPE) and mesenchymal stem cells (MSC), while the right half of the face  received microneedling. There were a total of 4 treatment sessions administered over 3 weeks. The final analysis of the data was conducted using the quantitative and qualitative scales developed by Goodman. The study involved 30 participants, After treatment, the severity of the acne scars on both sides was statistically significantly reduced according to Goodman and Baron's qualitative and quantitative methods. Right and left halves showed 38.54 ± 18.29 and 56.13 ± 15.25 improvements respectively, on Goodman's Quantitative scale. On the right half of the face, Goodman's Qualitative Scale revealed excellent response in 3 of patients, good response in 16, and poor response in 11 patients, while on the left half of the face, excellent response was seen in 14 of patients, good response in 10, and poor response in 6 of patients. We concluded that mesotherapy with human placental extract (HPE) and mesenchymal stem cells (MSC) is effective in the treatment of atrophic acne scars.